X-moxo-s



K Example k3 ,y

An ice-cold solution of 'Z0 partsby weight of ammonia gas and 307 parts by weight of -npropyl-a-isobutyl-fy-bromacetoacetic ester in 350 `parts byvweight of alcohol is left to stand` for .12H .n

hours, The course of thereaction can'be vfollowed by the precipitation of the 'ammonium' bromide; it is completed by heating vfor 6 hours to `50-60" C. The solution separated from ammonium ybromide is concentratedinIvacuo; The re' sidue is mixed with 3-normal caustic soda until.

definitely alkaline to phenolphthaleine. vThese-parated oil is taken up in benzene'and distilled in vacuo after removal of the benzene.

YThe dine distils over at y180-183" Crata pressure below 112mm: It can be dissolvednand allowed to crystallisefrom dibutyl ether. :Itmelts at 101f-102y C; and is rather 'dfcultly soluble vin water. l

, l yExample 4` i *in a freezing mixture of -ic'earid salt -4oo'pats vby weight of alcohol are' saturated withjabout where R and R." are alkyl groups each containing v 4. Process for the manufacture of a 2,4-dioxo- Y 3,3-dialkyl-pyrro1idine of which both alkyl groups :Icontain at least'jZ` lcarbon atoms each, comprising reacting an veeen;-fdialkyl-fy-halogen-acetoacetic ester in whichreachalkyl substituent contains at least two carbon atoms with ammonia.

5. -Process for the manufacture of a 2,4-dioxo- 3,3.-dialkyl-pyrrolidine of which both alkyl groups fcontain atleast 2 carbon atoms each, comprising reacting an a,a-dialkyl-fy-halogen-acetoacetic 'ester' in which each alkyl substituent contains at least two carbon atoms with ammonia in presenceof a solvent. Y

6. Process for the manufacture of 2,4-'dioxo- 3,3-diethyl-pyrrolidine, comprising reacting mdiethyl-vfhalogen-acetoacetic ester with ammonia.

7. Process for the manufacture of 2,4-dioxo- 3,3-diethyl-pyrrolidine, comprising reacting ,adiethyl-fy-bromoacetoacetic ester with ammonia in presence of alcohol.

8. Process for the manufacture of 2,4-dioxo- 3,3edipropylhpyrrolidine, comprising reacting ,adipropyl-fy-halogen-acetoacetic ,ester with am# vrnonira. "9'.'Process for themanufacture Vof 2,4-dioxo- ,-dipropyl-pyrrolidine, comprising reacting ,a-

dipropyl-'y-chloroacetoacetic ester with f ammonia in presence of methylalcohol.

' 10.'A process for the manufacture of a A2,4- dioxo3,3-dialkyl-pyrrolidine f' in which each of the alkyl groups contains two to six carbon atoms, which comprises reacting` an ,a-dialkyl-'y-halogen-acetoacetic ester in rwhich each alkyl substituent contains tWo to six carbon atoms with ammonia. f

11. A process for themanufacture of a 2,4-

` dioxo-3y3-dialkyl-pyrrolidine inl which each of stituent contains two to sixy carbon atoms with ammonia in the presence of the solvent.

O'ITO SCHNIDER. 

